脂联素与肿瘤坏死因子—α在子痫前期发病患者胎盘组织中的表达水平及意义(1)
[摘要] 目的 探讨脂联素(APN)与肿瘤坏死因子-α(TNF-α)在子痫前期(PE)发病患者胎盘组织中的表达水平及意义。 方法 选取2014年2月～2015年4月本院收治的35例PE患者作为观察组，选取同期在本院进行体检的35例健康晚期妊娠妇女作为对照组，采用放射免疫分析法对两组胎盘组织中的APN、TNF-α表达情况进行检测，并对胎盘组织中APN与TNF-α的相关性进行分析。 结果 观察组胎盘组织中的APN阳性表达显著低于对照组，TNF-α表达显著高于对照组，差异有统计学意义(P<0.05)。观察组中的APN表达与TNF-α呈负相关(P<0.05)。 结论 胎盘组织中的APN与TNF-α表达对PE患者病情的发展起到一定作用。
[关键词] 脂联素；肿瘤坏死因子-α；子痫前期
[中图分类号] R714.24+5 [文献标识码] A [文章编号] 1674-4721(2016)05(a)-0098-03
Expression level and significance of adiponectin and tumor necrosis factor-α in placental tissue in onset of patients with pre-eclampsia
MING Fang YANG Jie LV Xiu-fang
Department of Obstetrics，Maternal and Child Health Care Hospital of Baoan District in Shenzhen City；Maternal and Child Health Care Hospital of Baoan District in Shenzhen Affiliated to Jinan University 518000，China
[Abstract] Objective To explore the expression level and significance of adiponectin (APN) and tumor necrosis factor-α (TNF-α) of placental tissues in onset of patients with pre-eclampsia (PE). Methods 35 cases with PE in our hospital from February 2014 to April 2015 were selected as the observation group，and another 35 healthy pregnant women developed underwent physical examination in our hospital during the same period were selected as the control group.The level of APN，TNF-α in placental tissues of the research subjects in the two groups were detected by radio immunoassay，and the relationship between the APN and TNF-α level in the two groups was analyzed. Results The expression level of APN in placental tissues in the observation group was lower than that in the control group，the TNF-α level in the observation goup was higher than that in the control group，with significant difference (P<0.05).The expression level of APN in the study group was negatively correlated with the level of TNF-α (P<0.05). Conclusion The expression of APN and TNF-α in placental tissue play a certain role in the disease development of PE.
[Key words] Adiponectin；Tumor necrosis factor-α；Pre-eclampsia
子痫前期(pre-eclampsia，PE)是妊娠期较为常见的疾病，发病率呈逐年上升趋势，其可能是由于孕妇全身血管内皮细胞广泛损伤、动脉粥样硬化、胰岛素抵抗及脂质代谢紊乱所致，主要临床表现为妊娠期出现高血压、蛋白尿等，对母婴健康造成较大影响[1]。脂联素(adiponectin，APN)是脂肪细胞特异性血浆激素蛋白，可通过调节内皮细胞炎性反应而抑制血管平滑肌细胞的增生，进而达到修复内皮损伤的目的，其对PE的发生、发展具有极为重要的意义[2]。肿瘤坏死因子-α(TNF-α)具有双重作用，一方面可作为机体免疫防护的重要介质，另一方面可参与机体的免疫病理损伤。此外，有研究[3]显示，TNF-α可促使血管内皮细胞功能受损，参与PE的发病过程。本研究通过分析APN、TNF-α在PE发病患者胎盘组织中的表达水平及临床意义，旨在探讨APN、TNF-α在PE患者发病机制中的作用。
1 资料与方法
1.1 一般资料
选取2014年2月～2015年4月本院收治的35例PE患者作为观察组，年龄(28.42±3.46)岁，孕周(37.68±1.7)周，孕前BMI为(23.68±3.92) kg/m2，出生体质量为(2.98±0.27) kg，平均动脉压(MAP)为(80.24±13.63) mmHg。所有患者均符合《妇产科学》(第6版)的相关诊断标准[4]。同时选取同期的35例健康晚期妊娠妇女作为对照组，年龄(27.92±3.63)岁，孕周(38.26±2.13)周，孕前BMI为(22.91±3.46) kg/m2，出生体质量为(3.07±0.26) kg，MAP为(135.45±19.72) mmHg。两组以往均无高血压、心脏病、糖尿病及甲状腺功能亢进等；均无早产及感染现象。, http://www.100md.com(明芳 杨洁 吕秀芳)
[关键词] 脂联素；肿瘤坏死因子-α；子痫前期
[中图分类号] R714.24+5 [文献标识码] A [文章编号] 1674-4721(2016)05(a)-0098-03
Expression level and significance of adiponectin and tumor necrosis factor-α in placental tissue in onset of patients with pre-eclampsia
MING Fang YANG Jie LV Xiu-fang
Department of Obstetrics，Maternal and Child Health Care Hospital of Baoan District in Shenzhen City；Maternal and Child Health Care Hospital of Baoan District in Shenzhen Affiliated to Jinan University 518000，China
[Abstract] Objective To explore the expression level and significance of adiponectin (APN) and tumor necrosis factor-α (TNF-α) of placental tissues in onset of patients with pre-eclampsia (PE). Methods 35 cases with PE in our hospital from February 2014 to April 2015 were selected as the observation group，and another 35 healthy pregnant women developed underwent physical examination in our hospital during the same period were selected as the control group.The level of APN，TNF-α in placental tissues of the research subjects in the two groups were detected by radio immunoassay，and the relationship between the APN and TNF-α level in the two groups was analyzed. Results The expression level of APN in placental tissues in the observation group was lower than that in the control group，the TNF-α level in the observation goup was higher than that in the control group，with significant difference (P<0.05).The expression level of APN in the study group was negatively correlated with the level of TNF-α (P<0.05). Conclusion The expression of APN and TNF-α in placental tissue play a certain role in the disease development of PE.
[Key words] Adiponectin；Tumor necrosis factor-α；Pre-eclampsia
子痫前期(pre-eclampsia，PE)是妊娠期较为常见的疾病，发病率呈逐年上升趋势，其可能是由于孕妇全身血管内皮细胞广泛损伤、动脉粥样硬化、胰岛素抵抗及脂质代谢紊乱所致，主要临床表现为妊娠期出现高血压、蛋白尿等，对母婴健康造成较大影响[1]。脂联素(adiponectin，APN)是脂肪细胞特异性血浆激素蛋白，可通过调节内皮细胞炎性反应而抑制血管平滑肌细胞的增生，进而达到修复内皮损伤的目的，其对PE的发生、发展具有极为重要的意义[2]。肿瘤坏死因子-α(TNF-α)具有双重作用，一方面可作为机体免疫防护的重要介质，另一方面可参与机体的免疫病理损伤。此外，有研究[3]显示，TNF-α可促使血管内皮细胞功能受损，参与PE的发病过程。本研究通过分析APN、TNF-α在PE发病患者胎盘组织中的表达水平及临床意义，旨在探讨APN、TNF-α在PE患者发病机制中的作用。
1 资料与方法
1.1 一般资料
选取2014年2月～2015年4月本院收治的35例PE患者作为观察组，年龄(28.42±3.46)岁，孕周(37.68±1.7)周，孕前BMI为(23.68±3.92) kg/m2，出生体质量为(2.98±0.27) kg，平均动脉压(MAP)为(80.24±13.63) mmHg。所有患者均符合《妇产科学》(第6版)的相关诊断标准[4]。同时选取同期的35例健康晚期妊娠妇女作为对照组，年龄(27.92±3.63)岁，孕周(38.26±2.13)周，孕前BMI为(22.91±3.46) kg/m2，出生体质量为(3.07±0.26) kg，MAP为(135.45±19.72) mmHg。两组以往均无高血压、心脏病、糖尿病及甲状腺功能亢进等；均无早产及感染现象。, http://www.100md.com(明芳 杨洁 吕秀芳)